ZD 4190

Name	ZD-4190
Synonyms	ZD4190 ZD-4190 ZD 4190 4-Quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[2-(1H-1,2,3-triazol-1-yl)ethoxy]-
CAS	413599-62-9

Molecular Formula	C19H16BrFN6O2
Molar Mass	459.27
Solubility	DMSO
Storage Condition	-20℃
In vitro study	ZD4190 exhibits cytotoxic activity against the tumor cells.
In vivo study	ZD4190 (100 mg/kg, p.o.) effectively delays MDA-MB-435 tumor growth in mice. In ZD4190-treated tumors, 18F-FPPRGD2 uptake has decreased significantly relative to baseline by 26.74±8.12% (p<0.05) on day 1 and by 41.19±6.63% (p<0.01) on day 3, then has returned to baseline on day 7. Tumor uptake of 18F-FLT has also decreased on both day 1 and day 3 after initiation of ZD4190 treatment. However, ZD4190 does not significantly change 18F-FDG uptake in tumors, compared with the control group. ZD4190 (50 mg/kg, p.o.) prevents outgrowth of residual tumour in a muscle model of minimal residual carcinoma. ZD4190 (12.5-100 mg/kg, p.o.) produces a dose-dependent reduction in K(trans) in PC-3 prostate tumors. At 100 mg/kg, ZD4190 reduces K(trans) in PC-3 tumors by 31% following 2 doses and by 53% following 8 doses.

Last Update：2024-01-02 23:10:35

biological activity	ZD-4190 is a VEGF RTK inhibitor with IC50 values of 29±4 nM and 708±63 nM for KDR and Flt-1, respectively.
Target	Value

Last Update：2024-04-09 02:00:14

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CAS: 413599-62-9
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Spot supply

Product Name: ZD-4190 Visit Supplier Webpage Request for quotation
CAS: 413599-62-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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ZD 4190

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